Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 13, Issue 6, Pages 548-556Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0958-1669(02)00360-9
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Today, biocatalysis is a standard technology for the production of chemicals. An analysis of 134 industrial biotransformations reveals that hydrolases (44%) and redox biocatalysts (30%) are the most prominent categories. Most products are chiral (89%) and are used as fine chemicals. In the chemical industry, successful product developments involve on average a yield of 78%, a volumetric productivity of 15.5 g/(L.h) and a final product concentration of 108 g/L. By contrast, the pharmaceutical industry focuses on time-to-market. The implications of this for future research and development on biocatalysis are discussed.
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