Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 16, Issue 12, Pages 2425-2433Publisher
WILEY
DOI: 10.1046/j.1460-9568.2002.02404.x
Keywords
conditioned aversion; conditioned preference; intragastric infusions; lactose; lithium chloride; maltodextrin
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Funding
- NIDDK NIH HHS [DK-31135] Funding Source: Medline
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Food-restricted rats with ibotenic acid lesions of the lateral hypothalamus (LHx) learned to prefer a flavour paired with concurrent intragastric (i.g.) infusions of maltodextrin, although their preference was weaker than that displayed by sham controls. Unlike controls, the LHx rats failed to acquire a flavour preference when the i.g. maltodextrin infusion was delayed by 15 min. The same rats learned to avoid flavours paired with i.g. lactose or lithium chloride over short delays (15-30 min), but were impaired, relative to controls, at a long conditioned-unconditioned stimuli delay (2 h). These data indicate that the LH is critical for the formation of flavour-postingestive consequence learning over a delay, particularly with nutrient reinforcement. Lateral hypothalamus lesions might specifically impair the processing of nutrient-generated unconditioned stimuli and, more generally, could interfere with the maintenance of flavour memories.
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