Journal
PHYSIOLOGY & BEHAVIOR
Volume 77, Issue 4-5, Pages 477-482Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9384(02)00930-7
Keywords
cingulate; attention; conflict; interference; event-related potentials; functional magnetic resonance imaging; N2; error-related negativity; schizophrenia; obsessive-compulsive disorder
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We propose that the anterior cingulate cortex (ACC) contributes to cognition by detecting the presence of conflict during information processing, and to alert systems involved in top-down control to resolve this conflict. Here, we review several functional magnetic resonance imaging (fMRI) and event-related potential (ERP) studies that have used simple response interference tasks, and propose that ACC activity is activated prior to the response during correct conflict trials and reflected in the frontocentral N2, and immediately following error trials and reflected in the error-related negativity (ERN). Furthermore, we suggest that certain disturbances in cognition and behavior in common mental disorders such as schizophrenia and obsessive-compulsive disorder (OCD) can be understood as resulting from alteration in performance monitoring functions associated with this region of the brain. (C) 2002 Elsevier Science Inc. All rights reserved.
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