Journal
TRENDS IN IMMUNOLOGY
Volume 23, Issue 12, Pages 586-591Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(02)02326-8
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Despite readily detectable virus-specific CD8(+)T cells inmost HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development.
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