Journal
BIOSTATISTICS
Volume 3, Issue 4, Pages 445-457Publisher
OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/3.4.445
Keywords
bias in DerSimonian-Laird estimator; estimator of heterogeneity variance; meta-analysis; pooled analysis; population averaged study-specific weights; study-specific weights
Ask authors/readers for more resources
In this paper we consider estimating heterogeneity variance with the DerSimonian-Laird (DSL) estimator as typically used in meta-analysis. In its general form the DSL estimator requires inverse population-averaged study-specific variances as weights, in which case the estimator is unbiased. It has become common practice, however, to use estimates of the study-specific variances instead of their population-averaged versions. This can lead to considerable bias. Simulations illustrate these findings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available