Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 109, Issue 12, Pages 1499-1504Publisher
SPRINGER WIEN
DOI: 10.1007/s007020200097
Keywords
glaucoma; homocysteine; MTHFR polymorphism; glaucomatous optic neuropathy
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Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.
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