Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 3, Issue 12, Pages 932-943Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm977
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The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.
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