Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 3, Issue 12, Pages 919-931Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm974
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Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.
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