Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 133, Issue 1-2, Pages 72-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00367-3
Keywords
neuroprotection; T cells; organotypic slice culture; hippocampus; MBP; brain trauma
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This study analyzes how the antigen specificity, the subtype, and the activation state of T cells modulate their recently discovered neuroprotective potential. We assessed the prevention from neuronal damage in organotypic entorhinal-hippocampal slice cultures after coculture with Th1 and Th2 cells either specific for myelin basic protein (MBP) or ovalbumin (OVA). We found that MBP-specific Th2 cells were the most effective in preventing central nervous system (CNS) tissue from secondary injury. This neuroprotective T cell effect appears to be mediated by soluble factors. After stimulation with phorbol myristate acetate and ionomycin, all T cells were most effective in preventing neuronal death. Our data show that the T cell subtype and activation state are important features in determining the neuroprotective potential of these cells. (C) 2002 Elsevier Science B.V. All rights reserved.
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