Journal
STEROIDS
Volume 67, Issue 13-14, Pages 1041-1044Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0039-128X(02)00060-0
Keywords
oxysteroids; 26-hydroxycholesterol; diosgenin; modified Clemmensen reduction; Barton deoxygenation reaction; synthesis
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We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction. (C) 2002 Elsevier Science Inc. All rights reserved.
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