Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 25, Issue 6, Pages 824-830Publisher
PHARMACEUTICAL SOCIETY KOREA
DOI: 10.1007/BF02976999
Keywords
Euodia daniellii; Rutaceae; flavonoids; coumarins; steroids; limonoids; lignan; nucleoticle; inositol; cyclooxygenase-2; cytotoxicity
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Four flavonoid glycosides, flavaprin (7), evodioside B (8), vitexin (11), and hesperidin (12), as well as the coumarins bergapten (1), xanthotoxin (2), and isopimpinellin (3), the lignan simplexoside (10), the steroids P-sitosterol (4) and daucosterol (5), the limonoids isolimonexic acid (6) and limonin (9), and uracil (13) and myo-inositol (14) have been isolated from Euodia daniellii. The structures of these compounds were established from spectral data. Among the isolates, bergapten showed cyclooxygenase-2 inhibitory activity with an IC50 value of 6.2 mug/ml. Flavonoids isolated from this plant exhibited no cytotoxic activity against the human tumor cell lines, A549, SKOV-3, SKMEL-2, XF498, and HCT15.
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