4.5 Article

Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 12, Issue 23, Pages 3379-3382

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00761-8

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The anti-influenza activity of a series of thiobenzamide fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclo-hexylmethylamine is profiled. Axial disposition of the thioamide moiety is essential for potent influenza inhibitors activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

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