Journal
PHYSIOLOGICAL GENOMICS
Volume 11, Issue 3, Pages 133-164Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00074.2002
Keywords
gene targeting; homologous recombination; embryonic stem cell; mutagenesis; gene trap; mouse genome project
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In the postgenomic era the mouse will be central to the challenge of ascribing a function to the 40,000 or so genes that constitute our genome. In this review, we summarize some of the classic and modern approaches that have fueled the recent dramatic explosion in mouse genetics. Together with the sequencing of the mouse genome, these tools will have a profound effect on our ability to generate new and more accurate mouse models and thus provide a powerful insight into the function of human genes during the processes of both normal development and disease.
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