Journal
NEUROREPORT
Volume 13, Issue 17, Pages 2355-2358Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200212030-00037
Keywords
axon initial segment; clustering; GABA(A) receptor; gephyrin; hippocampal culture; immunocytochemistry; immunofluorescence; synapse
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Funding
- NINDS NIH HHS [NS39287, NS38752] Funding Source: Medline
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We have used triple-label fluorescence immunocytochemistry to demonstrate that as subunit-containing GABA(A) receptors (GA-BA(A)Rs) form large clusters at GABAergic synapses in dendrites and axon initial segment of cultured hippocampal neurons. The large synaptic clusters of alpha(5) subunit-containing GABA(A)Rs also contained alpha(1), beta(2/3), gamma(2) GABA(A)R subunits and gephyrin. The alpha(5) subunit-containing GABA(A)Rs also formed small clusters. The small clusters were not associated with GABAergic synapses and often did not co-localize with gephyrin.
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