Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 25, Pages 5604-5606Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm020310n
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- NIAID NIH HHS [AI45317] Funding Source: Medline
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A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 mug/mL) but only modest activity against MAC (MICs of 4-32 mug/mL).
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