Journal
NEUROSCIENCE LETTERS
Volume 334, Issue 1, Pages 68-70Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(02)01069-8
Keywords
cytokine; interleukin-1 beta; febrile convulsions; temporal lobe epilepsy; polymorphism; association study
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Recently, an association between a regulatory polymorphism in the gene encoding the pro-inflammatory cytokine interleukin (IL)-1beta and febrile convulsions (FC) has been reported. In this study we attempted to confirm these findings in a sample consisting of 99 FC patients and 126 ethnically matched controls. Since about 3% of all FC patients experience unprovoked seizures (epilepsy) later during life we furthermore genotyped 43 patients with non-lesional temporal lobe epilepsy who reported a history of FC. In both samples we failed to show an association between the IL-1beta polymorphism and an increased risk for FC. We only found a trend towards an increased frequency and carriage of the putative IL-1beta susceptibility allele two in a sub-sample of 43 FC patients who reported a positive family history for seizures in first and/or second degree relatives. However, these trends did not reach statistical significance. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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