Journal
SCIENCE
Volume 298, Issue 5600, Pages 1946-1950Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1072162
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The eggs of Caenorhabditis elegans and Drosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the par genes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.
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