Journal
AIDS
Volume 16, Issue 18, Pages 2487-2489Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200212060-00019
Keywords
-
Categories
Ask authors/readers for more resources
Diurnal variation in plasma concentrations of nelfinavir and ritonavir has previously been described. Plasma concentrations of 29 pharmacokinetic profiles with indinavir, amprenavir and saquinavir were evaluated, and a statistically significant median difference of 57.6% was found between morning and evening, with the morning C-through being higher than the evening C-through.Consequently, a change in dosing intervals might result in more balanced plasma protease inhibitor concentrations, thereby decreasing toxicity and the risk of virological failure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available