Journal
ONCOGENE
Volume 21, Issue 56, Pages 8643-8651Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1206091
Keywords
CML; tyrosine kinase; retrovirus; Philadelphia chromosome
Funding
- NCI NIH HHS [CA90576] Funding Source: Medline
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Animal models of BCR-ABL(+) leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ability to recapitulate precisely the phenotypes of BCR-ABL(+) leukemias in vivo, but this comes at the price of significant complexity. Here I review recent studies of leukemias induced in mice by BCR-ABL with an emphasis on the intricate nature of these diseases and the need for careful pathological and molecular analysis.
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