Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 99, Issue 25, Pages 16203-16208Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.212646299
Keywords
gene expression profiling; DNA microarray; mucosal immunity; gastritis; Helicobacter
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We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximate to30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.
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