Journal
ORGANIC LETTERS
Volume 4, Issue 25, Pages 4519-4522Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol027048x
Keywords
-
Categories
Funding
- NCI NIH HHS [CA27489] Funding Source: Medline
Ask authors/readers for more resources
[GRAPHICS] One-pot asymmetric Mannich-hydrocyanation reactions are described. Reaction of unmodified aldehydes with MPMP-protected alpha-imino ethyl glyoxylate in the presence of catalytic amounts of L-proline followed by the addition of Et2AlCN provided highly enantiomerically pure beta-cyanohydroxymethyl alpha-amino acid derivatives possessing three contiguous stereogenic centers as single diastereomers (93-99% ee). Control of reaction temperature during the cyanation step directed whether cyclization of the products to lactones occurred.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available