4.8 Article

Discodermolide/dictyostatin hybrids: Synthesis and biological evaluation

Journal

ORGANIC LETTERS
Volume 4, Issue 25, Pages 4443-4446

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol026942l

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Funding

  1. NCI NIH HHS [CA78039] Funding Source: Medline

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[GRAPHICS] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.

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