Journal
ONCOGENE
Volume 21, Issue 58, Pages 9043-9056Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1205958
Keywords
pyrimidine dimers; DNA photorepair; circadian clock; photosensory pigment
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Blue light governs a number of cellular responses in bacteria, plants, and animals, including photoreactivation, plant development, and circadian photoentrainment. These activities are mediated by a family of highly conserved flavoproteins, the photolyase/cryptochrome family. Photolyase binds to UV photoproducts in DNA and repairs them in a process called photoreactivation in which blue light is used to initiate a cyclic electron transfer to break bonds and restore the integrity of DNA. Cryptochrome, which has a high degree of sequence identity to photolyase, works as the main circadian photoreceptor and as a component of the molecular clock in animals, including mammals, and regulates growth and development in plants.
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