Journal
NEURON
Volume 36, Issue 6, Pages 1195-1210Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(02)01061-9
Keywords
-
Categories
Funding
- NCRR NIH HHS [RR08079, S10 RR13957] Funding Source: Medline
- NIBIB NIH HHS [EB000331] Funding Source: Medline
- NIMH NIH HHS [MH55346] Funding Source: Medline
Ask authors/readers for more resources
Most fMRI studies are based on the detection of a positive BOLD response (PBR). Here, we demonstrate and characterize a robust sustained negative BOLD response (NBR) in the human occipital cortex, triggered by stimulating part of the visual field. The NBR was spatially adjacent to but segregated from the PBR. It depended on the stimulus and thus on the pattern of neuronal activity. The time courses of the NBR and PBR were similar, and their amplitudes covaried both with increasing stimulus duration and increasing stimulus contrast. The NBR was associated with reductions in blood flow and with decreases in oxygen consumption. Our findings support the contribution to the NBR of (1) a significant component of reduction in neuronal activity and (2) possibly a component of hemodynamic changes independent of the local changes in neuronal activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available