Solid-phase synthesis of C-terminal thio-linked glycopeptides

A solid-phase Mitsunobu reaction between a resin-bound 1-thiosugar and an N-Fmoc protected amino alcohol was successfully employed for thio-linked glycopeptide synthesis. Facile cleavage and deprotection in one step afforded the target glycopeptide in good yield and purity. (C) 2002 Elsevier Science Ltd. All rights reserved.