Journal
TETRAHEDRON LETTERS
Volume 43, Issue 52, Pages 9531-9533Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)02418-8
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The diastereoselective synthesis of enantiopure differentially protected cis-4,5-diaminopiperidin-2-one was achieved by means of conjugate addition of ammonia to an unsaturated gamma-lactam and transamidation reaction with ring expansion as the main steps. (C) 2002 Elsevier Science Ltd. All rights reserved.
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