Journal
NATURE
Volume 420, Issue 6917, Pages 860-867Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature01322
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Funding
- NCI NIH HHS [R01 CA057621-07, R01 CA057621, P01 CA072006-08, P01 CA072006] Funding Source: Medline
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Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new antiinflammatory therapeutic approaches to cancer development.
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