Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Volume 357, Issue 1428, Pages 1851-1857Publisher
ROYAL SOC LONDON
DOI: 10.1098/rstb.2002.1162
Keywords
long-term potentiation; long-term depression; spike timing
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Funding
- NIMH NIH HHS [R01 MH066338] Funding Source: Medline
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Debate has raged over the past few years as to whether cortical neurons transmit information primarily in their average firing rates or in the precise timing of their spikes. Here, we address the related question of which features of spike trains control plasticity at cortical synapses. Using paired recording in slices we have developed a quantitative and predictive description of the joint dependence of cortical plasticity on the rate and relative timing of pre- and postsynaptic firing. The results hold important implications for which parts of the neural code are most readily stored for later retrieval.
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