Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1585, Issue 2-3, Pages 146-152Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1388-1981(02)00335-9
Keywords
serine palmitoyltransferase; ceramide; stress response
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Serine palmitoyltransferase is the first and rate-limiting enzyme of sphingolipid synthesis. As such, it is a central control point in the synthesis of bioactivate sphingolipids, and it plays an important role in mediating cellular stress responses. In this review, its role in mediating these responses is discussed within the context of de novo ceramide synthesis. Furthermore, a discussion is provided of its regulation as discerned from both yeast and mammalian studies. (C) 2002 Elsevier Science B.V. All rights reserved.
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