Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 121, Issue 1-2, Pages 111-134Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0009-3084(02)00157-3
Keywords
anandamide; N-acylethanolamine; N-acyl PE; 2-arachidonoylglycerol; metabolism; cell signaling
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Funding
- NHLBI NIH HHS [HL08214, HL24312] Funding Source: Medline
- NIGMS NIH HHS [GM45741] Funding Source: Medline
- NINDS NIH HHS [NS14304] Funding Source: Medline
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The major endocannabinoids, anandamide (N-arachidonoylethanolamide, 20:4n-6 N-acylethanolamine) and 2-arachidonoylglycerol (2-AG) are structurally and functionally similar, but they are produced by different metabolic pathways and their levels must therefore be regulated by different mechanisms. Both endocannabinoids are accompanied by cannabinoid receptor-inactive, saturated and mono- or di-unsaturated congeners which can influence their metabolism and function. Here we review published data on the presence and production of anandamide and 2-AG and their congeners in mammalian cells and discuss this information in terms of their proposed signaling functions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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