Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 458, Issue 3, Pages 275-282Publisher
ELSEVIER
DOI: 10.1016/S0014-2999(02)02792-9
Keywords
allodynia; antiarrhythmic; anticonvulsant; gazelius nerve injury; hyperalgesia; spared nerve injury
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The pain-relieving effects of various voltage-activated Na+ channel blockers have been evaluated in two rat models of neuropathic pain; the photochemically induced nerve injury model (Gazelius) and spared nerve injury model. Lidocaine (up to 40 mg/kg, i.p.) and lamotrigine (up to 60 mg/kg, i.p.) had no effect on mechanical or cold allodynia in either model. However, lamotrigine (10, 30 and 60 mg/kg) significantly attenuated mechanical hyperalgesia in the spared nerve injury model, while mexiletine (25 and 37.5 mg/kg, i.p.) attenuated mechanical allodynia in the Gazelius model. Tocainide (50, 75 and 100 mg/kg, i.p.) significantly reduced all types of pain behaviour measured. The present results show that these voltage-activated Na+ channel blockers have broadly similar aminociceptive effects in these two models of neuropathic pain. They also show that these drugs can have markedly different effects on distinct neuropathic pain-related behaviours within models. (C) 2002 Elsevier Science B.V. All rights reserved.
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