Journal
TETRAHEDRON LETTERS
Volume 44, Issue 2, Pages 387-389Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)02500-5
Keywords
artemisinin; stereoselective; iodolactone; tris(trimethylsilyl)silane
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The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis. (C) 2002 Published by Elsevier Science Ltd.
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