4.4 Article

Calcite and fluorite as catalyst for the Knovenagel condensation of malononitrile and methyl cyanoacetate under solvent-free conditions

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 2, Pages 399-401

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)02431-0

Keywords

Knovenagel condensations; solid phase synthesis; nitrites; catalysts

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When milled together with calcite or fluorite, malononitrile and methyl cyanoacetate readily underwent Knovenagel condensation with aromatic aldehydes. giving the corresponding arylidenemalononitriles and (E)-alpha-cyanocinnamic esters in good to excellent yield. (C) 2002 Elsevier Science Ltd. All rights reserved.

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