Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 1, Pages 289-294Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0136913100
Keywords
-
Categories
Funding
- NCRR NIH HHS [P41 RR001192] Funding Source: Medline
- NIDA NIH HHS [K05 DA000074, DA-00074] Funding Source: Medline
- NIMH NIH HHS [R37 MH018501, R01 MH018501] Funding Source: Medline
- NINDS NIH HHS [R01 NS034172, NS-34172] Funding Source: Medline
Ask authors/readers for more resources
Disrupted-in-Schizophrenia-1 (DISC-1) is a gene whose mutant truncation is associated with major psychiatric illness with a predominance of schizophrenic symptomatology. We have cloned and characterized rodent DISC-1. DISC-1 expression displays pronounced developmental regulation with the highest levels in late embryonic life when the cerebral cortex develops. In yeast two-hybrid analyses, DISC-1 interacts with a variety of cytoskeletal proteins. One of these, NudE-like (NUDEL), is associated with cortical development and is linked to LIS-11, the disease gene for a form of lissencephaly, a disorder of cortical development. The disease mutant form of DISC-11 fails to bind NUDEL. Expression of mutant, but not wild-type, DISC-11 in PC12 cells reduces neurite extension. As schizophrenia is thought to reflect defects in cortical development that are determined by cytoskeletal protein activities, the cellular disturbances we observe with mutant DISC-11 may be relevant to psychopathologic mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available