Journal
NEURON
Volume 37, Issue 1, Pages 135-147Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(02)01129-7
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Funding
- NIMH NIH HHS [MH26212] Funding Source: Medline
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Using a simplified preparation of the Aplysia siphon-withdrawal reflex, we previously found that associative plasticity at synapses between sensory neurons and motor neurons contributes importantly to classical conditioning of the reflex. We have now tested the roles in that plasticity of two associative cellular mechanisms: activity-dependent enhancement of presynaptic facilitation and postsynaptically induced longterm potentiation. By perturbing molecular signaling pathways in individual neurons, we have provided the most direct evidence to date that each of these mechanisms contributes to behavioral learning. In addition, our results suggest that the two mechanisms are not independent but rather interact through retrograde signaling.
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