Journal
SCIENCE
Volume 299, Issue 5604, Pages 245-247Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1077293
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Funding
- NEI NIH HHS [R01 EY014596-01, R37 EY006837, R37 EY006837-15, R01 EY006837-16A1, R37 EY006837-14, R37 EY006837-13, R01 EY014596, R37 EY006837-15S1, R01 EY006837] Funding Source: Medline
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In the mammalian retina, a small subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, express the opsin-like protein melanopsin, and project to brain nuclei involved in non image-forming visual functions such as pupillary light re ex and circadian photoentrainment. We report that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged. These animals showed a pupillary light re ex indistinguishable from that of the wild type at low irradiances, but at high irradiances the re ex was incomplete, a pattern that suggests that the melanopsin-associated system and the classical rod/cone system are complementary in function.
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