Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 2, Pages 217-224Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00229
Keywords
transforming growth factor-beta; activation; sensor
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Funding
- NCI NIH HHS [CA34282, CA78422] Funding Source: Medline
- NHLBI NIH HHS [HL 63786] Funding Source: Medline
- NIDCR NIH HHS [DE13742] Funding Source: Medline
- NIGMS NIH HHS [T32 GM07308] Funding Source: Medline
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TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, 'TGFbeta activators,' release TGFbeta from its latent state. The unusual temporal discontinuity of TGFbeta synthesis and action and the panoply of TGFbeta effects contribute to the interest in TGF-beta. However, the logical connections between TGFbeta synthesis, storage and action are obscure. We consider the latent TGFbeta complex as an extracellular sensor in which the TGFbeta propeptide functions as the detector, latent-TGFbeta-binding protein (LTBP) functions as the localizer, and TGF-beta functions as the effector. Such a view provides a logical continuity for various aspects of TGFbeta biology and allows us to appreciate TGFbeta biology from a new perspective.
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