Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 30, Issue 6, Pages 1715-1724Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0731-7085(02)00513-7
Keywords
nicotinic agonists; nicotinic antagonists; non-competitive inhibitors; affinity chromatography; immobilized receptors
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The nicotinic acetylcholine receptor (nAChR) subtypes alpha3beta4-nAChR and alpha4beta2-nAChR have been immobilized and the resulting stationary phases used to determine binding affinities. The alpha3beta4-nAUR column was coupled to a C-18 column and a mixture of 18 compounds was sorted into ligands and non-ligands for the alpha3beta4-nAUR. The results demonstrate that the nAChR stationary phases can be used for on-line high-throughput screening (HTS). Published by Elsevier Science B.V.
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