Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 2, Pages 211-216Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00248
Keywords
nuclear migration; nuclear anchorage; UNC-84; SUN domain; ANG-1; muscular dystrophy; nuclear envelope
Categories
Funding
- NIGMS NIH HHS [F32 GM020127] Funding Source: Medline
Ask authors/readers for more resources
Mechanisms for nuclear migration and nuclear anchorage function together to control nuclear positioning. Both tubulin and actin networks play important roles in nuclear positioning. The actin cytoskeleton. has been shown to position nuclei in a variety of systems from yeast to plants and animals. It can either act as a stable skeleton to anchor nuclei or supply the active force to move nuclei. Two C elegans genes and their homologues play important roles in these processes. Syne/ANC-1 anchors nuclei by directly tethering the nuclear envelope to the actin cytoskeleton, and UNC-84/SUN functions at the nuclear envelope to recruit Syne/ANC-1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available