Journal
BRAIN RESEARCH
Volume 960, Issue 1-2, Pages 273-276Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03805-2
Keywords
cerebral ischemia; middle cerebral artery occlusion; NS398; COX-2 inhibitor
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This study was designed to investigate the time lag of effect of NS398, selective COX-2 inhibitor, on infarct volume and neurologic deficits in mice with experimentally-induced cerebral ischemia. Our results showed that the beneficial effect of NS398 on reduction of infarct volume and improvement of neurologic deficits were noted more than 24 h after the injection regardless of the administration timing. (C) 2002 Elsevier Science B.V. All rights reserved.
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