Journal
SCIENCE
Volume 299, Issue 5605, Pages 405-408Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1079546
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Funding
- NHLBI NIH HHS [HL 64597] Funding Source: Medline
- NICHD NIH HHS [U01 HD 42283] Funding Source: Medline
- NIDCR NIH HHS [DE 07244] Funding Source: Medline
- NIGMS NIH HHS [R37GM23547] Funding Source: Medline
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Trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. At the maternal-fetal interface, we investigated the expression of selectin adhesion systems that enable leukocyte capture from the bloodstream. On the maternal side, human uterine epithelial cells up-regulated selectin oligosaccharide-based ligands during the window of receptivity. On the fetal side, human trophoblasts expressed L-selectin. This ligand-receptor system was functional, because beads coated with the selectin ligand 6-sulfo sLe(x) bound to trophoblasts, and trophoblasts bound to ligand-expressing uterine luminal epithelium in tissue sections. These results suggest that trophoblast L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy.
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