Journal
BRAIN RESEARCH
Volume 960, Issue 1-2, Pages 263-266Publisher
ELSEVIER
DOI: 10.1016/S0006-8993(02)03697-1
Keywords
MPEP; mGlu5 receptor; pain; visceral; Fos; rat
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In this study, we examined the effects of the glutamate metabotropic subtype 5 (mGlu5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on Fos expression in the spinal cord in a model of visceral pain in the rat. We show that noxious stimulation increases the number of Fos-positive neurons in the dorsal horn of the thoracic and lumbar spinal cord, and that pretreatment with MPEP significantly reduces the number of Fos-positive neurons in these areas. These data indicate that mGlu5 is involved in the transmission of visceral pain in the spinal cord, (C) 2002 Elsevier Science B.V. All rights reserved.
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