Journal
NEUROREPORT
Volume 14, Issue 1, Pages 73-76Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200301200-00014
Keywords
Alzheimer's disease; multiple system atrophy; Parkinson's disease; progressive supranuclear palsy; serotonin
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Neurodegenerative diseases share symptoms suggested to be related to the serotonergic system. To evaluate the involvement of serotonergic raphe nuclei, we compared the percentage of neurons synthesizing serotonin in the nucleus centralis superior (NCS), raphe obscurus and pallidus (NROP) in Alzheimer's disease (AD), progressive supranuclear palsy (PSP), Parkinson's disease (PD), multiple system atrophy (MSA), and control brains. We used immunohistochemistry for tryptophan hydroxylase (TpOH), phosphorylated tau, and alpha-synuclein. We observed a significant decrease in the NCS in the NROP in AD, but a significant increase in PSP and IMSA. Cytoskeletal pathology was present in the NCS and NROP to a variable degree. We conclude that there is disease- and nucleus-specific alteration of serotonin synthesis in the raphe.
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