4.5 Article

Dihydropyrimidinones -: A new class of anti-staphylococcal antibiotics

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 13, Issue 2, Pages 241-245

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00880-6

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We report the synthesis and pharmacological evaluation of new derivatives of natural dipeptide antibiotic TAN-1057 A, B. In the course of this program, we identified novel analogues of the natural product that display similar antibacterial activity and showed improved tolerability. (C) 2002 Elsevier Science Ltd. All rights reserved.

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