Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 103, Issue 3, Pages 427-430Publisher
WILEY
DOI: 10.1002/ijc.10814
Keywords
BRCA2; polymorphism; ovarian cancer
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The BRCA2 372 HH genotype defined by the BRCA2 N372H nonconservative amino acid substitution polymorphism was recently reported to be associated with a small increased risk of breast cancer. We investigated whether this polymorphism was associated with ovarian cancer risk by conducting British and Australian case-control comparisons in Para e including a total sample of 1,121 ovarian cancer cases an 2,643 controls. There was no difference in genotype frequency between control groups from the 2 studies (p=0.9). The HH genotype was associated with an increased risk of ovarian cancer in both studies, and the risk estimate for the pooled studies was 1.36 (95% CI 1.04-1.77, p=0.03). There was also a suggestion that this risk may be greater for ovarian cancers of the serous subtype for both studies, with an OR (95% CI) of 1.66 (1.17-2.54) for the 2 studies combined (p=0.005). The BRCA2 372 HH genotype appears to be associated with an increased risk of ovarian cancer of a similar magnitude to that reported for breast cancer. (C) 2002 Wiley-Liss, Inc.
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