Journal
IMMUNOLOGY LETTERS
Volume 85, Issue 2, Pages 197-203Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-2478(02)00231-6
Keywords
Slc11a1; Nramp1; resistance to infection; autoimmune disease susceptibility
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Funding
- Wellcome Trust [065642] Funding Source: Medline
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Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages: (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1 and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.
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