Journal
ORGANIC LETTERS
Volume 5, Issue 2, Pages 133-136Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol027061h
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The formation of 2-aminobenzimidazoles via intramolecular C-N bond formation between an aryl halide and a guanidine moiety can be achieved using either copper or palladium catalysis. Inexpensive copper salts such as Cul are generally superior to the use of palladium catalysts. Regioselective cyclizations, where R-3 = H, can be achieved in high yield under Cul/1,10-phenanthroline-catalyzed conditions, whereas palladium catalysis results in the formation of regioisomeric products.
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