Journal
BRAIN RESEARCH
Volume 961, Issue 1, Pages 92-99Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03892-1
Keywords
sigma(1) (sigma(1))-receptor; oligodendrocytes; immunohistochemistry; rat brain
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By using a new polyclonal antibody raised against a 21-amino acid peptide sequence corresponding to the fragment 138-157 of the cloned rat sigma(1)-receptor, we demonstrated by immunoperoxidase and double immunofluorescence techniques, that rat oligodendrocytes express the sigma(1)-receptor. Experiments in vivo and in vitro showed that sigma(1)-receptor colocalized with specific markers of progenitor (A2B5) and mature oligodendrocytes (GalC, RIP). These results suggest that sigma(1)-receptor in oligodendrocytes might be involved in myelination by direct implication in cholesterol biosynthesis or by interaction with endogenous ligands such as neurosteroids. (C) 2002 Elsevier Science B.V. All rights reserved.
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