Journal
TETRAHEDRON LETTERS
Volume 44, Issue 5, Pages 1051-1053Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)02727-2
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A simple, efficient, and general method has been developed for the synthesis of I-aminophosphonates from 1-hydroxyphosphonates under solvent-free conditions using microwave irradiation. I-Aminophosphonates were obtained in high yield and mild conditions by reaction of diethyl 1-hydroxyalkylphosphonates with arnines in the presence of acidic alumina. (C) 2003 Elsevier Science Ltd. All rights reserved.
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