Journal
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
Volume 65, Issue 1, Pages 139-147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-7439(02)00045-X
Keywords
mixture experimental design; pharmaceutical formulation; poloxamer 407; gel; tolfenamic acid
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The aim of this tutorial is to show the application of a mixture experimental design to a problem of pharmaceutical formulation. A gel, based on poloxamer 407, useful for topical administration of tolfenamic acid, a potent anti-inflammatory drug very poorly soluble in water, has been prepared, and a mixture experimental design was used to study the influence of the components on the viscosity of the formulation. Its application allowed to identify a critical boundary, separating semisolid formulations from liquid ones, within a narrow interval of concentrations of the components, and to estimate their effects on the viscosity of the preparation. (C) 2002 Elsevier Science B.V. All rights reserved.
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